Drug induced diabetes mellitus

drug induced diabetes mellitus

Modeling long-term diabetes and related complications in rats J Pharmacol Toxicol Methods.

Full size table Experimental design A To investigate the effect of DDW on metabolic changes occur in diabetes, diabetic and control rats were divided into two main groups: half of the animals were given DDW 25 ppm Dand the other half received normal tap water ppm Dboth provided ad libitum. To determine whether DDW exerts its effects, at least partially, by modifying the action of insulin, diabetic rats were further divided into subgroups according to insulin treatment. The control rats did not receive insulin treatment. We did not want to achieve euglycaemia by insulin treatment, but to prevent severe acute complications only.

Mar-Apr ; Epub Nov Gyömrői út Electronic address: erika. DOI: The aims of this study were to establish a model of long-term diabetes with sustained medium scale hyperglycemia and characterize the pathological changes detectable after 4months, with particular respect to dependence on the degree of hyperglycemia.

drug induced diabetes mellitus a diabetes mellitus kezelése 1. típusú izrael

Methods: Streptozotocin-induced diabetic CFY rats were subjected to four different insulin substitution protocols to achieve different levels of glycemic control Diabetic drug induced diabetes mellitus. Eyes were investigated by ophthalmoscopy, kidney function by urine analysis, and neuropathy by functional tests. Retinal and renal morphological evaluations were performed by histology, immuno-histochemistry and electron microscopy.

8 Diabetic Signs \u0026 Symptoms You Must Never Ignore! SugarMD

Discussion: We established a treatment protocol in rats enabling complex investigation of diabetic retinopathy, nephropathy and neuropathy on a long-term period. Clearly hyperglycemic dependent parameters of these complications serve as good outcome measures for preclinical trials.

drug induced diabetes mellitus cukorbetegség és a kezelés a hagyományos módszerekkel

Our results provide a useful basis for designing studies for testing preventative treatments as well as other translational medical research diabetes kezelés németország this field.

Keywords: Anterior segment neovascularization; Chronic model; Cold allodynia; Diabetic nephropathy; Diabetic neuropathy; Diabetic retinopathy; Drug development; Insulin implant; Preclinical model; Streptozotocin.

Protective effects of the novel amine-oxidase inhibitor multi-target drug SZV on streptozotocin-induced beta cell damage and diabetic complications in rats Biomed Pharmacother.

Copyright © Elsevier Inc. All rights reserved. Publication types.

drug induced diabetes mellitus kezelése zsibbadás stop diabetes mellitus

vélemények