Diabetic nephropathy and elevated blood pressure

Belgyógyászati KlinikaBudapest, Korányi S. A társaságok tagjai számára ingyenes. A folyóiratban megjelenõ közleményekrõl külön lenyomat A folyóiratban valamennyi írásos és képi anyag közlési joga a szerkesztõséget illeti. A megjelent anyag, illetve annak egy részének bármilyen formában történõ másolásához, ismételt megjelentetéséhez a szerkesztõség hozzájárulása szükséges. On the one hand, renal dysfunction and particularly renal disease can cause an increase in blood pressure, while on the other hand, high blood pressure accelerates loss of function of the diseased kidney.

Transplantation studies, both in experimental animals and humans, documented that blood pressure goes with the kidney : a normotensive recipient of a kidney genetically programmed for hypertension will become hypertensive, while conversely hypertensive patients with diabetic nephropathy and elevated blood pressure failure receiving the kidney of a normotensive donor may become normotensive.

Family studies showed higher blood pressure values and more frequent hypertension in first degree relatives of patients with primary glomerulonephritis or diabetic nephropathy, suggesting that genes coding for hypertension increase also the risk of renal disease.

Diéta a 2. típusú cukorbetegségből

The mechanisms through which blood pressure increases in renal disease comprise: salt and water retention, inappropriate activity of the renin angiotensin system RAS and of the sympathetic nerve system as well as impaired endothelial cell-mediated vasodilatation. There is ample evidence, both in primary renal disease and in nephropathy of type 1 or type 2 diabetes, that pharmacological blockade of the RAS by angiotensin converting enzyme inhibitors ACEI or angiotensin II type 1 receptor blockers ATRB has blood pressure-independent renoprotective effects, and may reduce proteinuria.

Since, according to recent concepts, proteinuria is a nephrotoxin, apart from blood pressure, proteinuria is a further and partially blood pressure independent indication for antihypertensive treatment using ACEI or ATRB for patients with diabetic nephropathy or primary renal diseases. Brenner 1 proposed the hypothesis, that deviations of the kidney structure are found in patients with so called essential hypertension i.

This hypothesis is supported by a number of experimental and clinical observations. Stereologic investigation of the kidney revealed significant glomerular enlargement 2.

sóska ló a cukorbetegség kezelésében legújabb kezelésére szolgáló hatóanyagok a 2. típusú cukorbetegség

Similarly, in the bacground of spontaneous hypertension, proteinuria, and glomerulosclerosis of MWF rats, a reduced nephron number was detected with stereologic methods 3. The number of glomeruli and glomerular volume were investigated stereologically with a modified Gundersen fractionator method.

A significantly lower number of glomeruli per kidney was noted in hypertensive individuals than in the matched controls Figure 1. At the same time, the glomerular volume was significantly greater in hypertensive individuals than in matched controls Figure 1. Such increase in glomerular volume may constitute a compensatory mechanism.

Of course it was important to exclude one artefact, i. In this study there was no histological evidence of glomerular diabetic nephropathy and elevated blood pressure hypertensive nephropathy.

The findings of this postmortal human study fits nicely with a series of animal experiments which have shown that hypertension and normotension can be transferred from a donor to a recipient by transplanting a kidney, i.

The most elegant studies on this topics were reported by Rettig et al 6. He showed that, transplantation of a kidney from a genetically hypertensionprone donor rat, even when it had been kept normotensive from weaning by antihypertensive medication, caused a progressive increase of blood pressure in a recipient animal which was immunologically manipulated to prevent rejection.

Introduction

This finding is extremely interesting: a kidney genetically programmed to develop high blood pressure forces an organism programmed for normotension to develop hypertension, although the recipient s central nervous system, volume control systems, sympathetic nervous system, heart function etc are all geared diabetic nephropathy and elevated blood pressure normotension.

In contrast, and quantitatively less impressive, transplantation of a kidney from a donor genetically programmed for normotension lowered blood pressure in the recipient 7. Although animal experiments are very nice, most reader of this paper deal with hypertensive patients and not hypertensive rats.

Is the above experimental observation also true for humans? Of course, no controlled studies are available where kidneys from patients with essential hypertension were transplanted to normotensive recipients or conversely. However uncontrolled data strongly suggest that recipients of kidneys from donors with essential hypertension develop hypertension more frequently than recipients of kidneys from normotensive donors 8, 9.

It has also been shown that kidney graft recipients required more antihypertensive medication if the grafts had been obtained from genetically hypertension-prone donors 8. In particular, recipients of kidneys from donors dying from cerebral hemorrhage, presumably caused by hypertension, had a higher risk to develop hypertension 9.

Because of numerous scores ±0. However, Curtis et al 11 showed very convincingly, that conversly, the transplantation of a kidney from a normotensive donor can permamently normalise the blood pressure of recipients with essential hypertension.

Hypertension and nephrology

He studied 6 black patients with essential hypertension of unknown origin who became dialysis dependent as a result of hypertensive nephrosclerosis without any histologic signs of primary kidney disease.

After these patients had received a kidney from a normotensive donor, all of them became normotensive and this persisted during a 4.

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  • Cukormérő tű
  • Search Menu Abstract Background.
  • Sebészeti eljárás diabetes
  • Diabetikus nephrosclerosis
  • Cairo University Rövid összefoglaló A diabéteszes nephropathia DN a krónikus vesebetegség és a proteinuria gyakori oka nem elrettentő tényező a cukorbetegek végstádiumú vesebetegségében.

There was evidence of reversal of hypertensive damage to the heart and retinal vessels, and of completely normal blood pressure responses to salt deprivation and salt loading. Which factors, genetic or environmental, could be potentially responsible for the hypertensinogenic effects of the kidney and, according to Brenner s hypothesis for so called nephron underdosing?

Since the pioneering experiment of Weitz in the ies of the last century we know that genetic factors play a key role in essential hypertension We must, therefore, suppose that the number of functional nephrons is genetically determined.

This hypothesis is also supported by the race dependent differences in glomerular count in humans However, there are also many animal experiments and human studies which suggest that during the fetal period environmental factors may also influence renal 0. Langley et al 14 have shown that dietary protein restriction of pregnant rats caused high blood pressure in the offspring.

In humans Merlet-Benichou et al 15 showed that newborns with lower birth weight as an indirect sign of fetal malnutrition had a lower nephron number than newborns with normal birth weight.

A lower sodium level — 1, milligrams mg a day — is appropriate for people 51 years Maintain a healthy weight. Az orvosok a betegség osztályozását ajánlják, az okától és a fő tüneteitől kezdve: hipertóniás, ateroszklerotikus, diabetikus nephrosclerosis. Ha a hipertóniás.

The role of the kidney in the pathogenesis of essential hypertension is probably not only due to potential structural alterations, such as lower nephron number, but also due to changes in kidney function. According to this concept, because the gain of the blood-pressure-natriuresis relationship overrides all other regulatory systems, the ultimate determinant of blood pressure must always be the renal handling of sodium.

It is interesting that renal function, as reflected by the blood pressure-natriuresis relationship, can be disturbed as a consequence of extrarenal causes. Lombardi et al 17 performed a very interesting experiment. However when normotensive rats had temporarily been rendered hypertensive by infusing angiotensin II and after they had subsequently become normotensive when angiotensin II infusion had been stopped, they had permanently become sodium sensitive.

The kidney remembered so to speak the injury induced by angiotensin II. If these animals were later exposed to a high sodium intake their blood pressure increased and they again developed hypertension. The shift of the blood pressure-natriuresisrelationship under hormonal influences such as mineralo and glucocorticoid excess 18testosteron 19 and estrogen 20 etc is well known.

However it is also interesting that for example dietary factors such as high intake of unsaturated fatty acid 21or high potassium intake 22, 23 can shift this relationship. These experimental findings prompted the DASH study, designed to investigate the influence of such dietary factors on blood pressure in humans Which mechanisms cause the increase of blood pressure in kidney disease? Elegant evidence for disturbed renal sodium excretion leading to hypervolemia was provided by Schmid et al In his study blood pressure of patients with polycystic kidney disease PKD was increased after a high sodium load, even when glomerular filtration was still normal.

In PKD patients, concentrations of atrial natriuretic peptide ANP were higher indicating hypervolemia, both at low and high sodium intake. It is well known that in patients with primary renal disease the activity of the renin-angiotensin system is inadequately high. Kuczera et al 26 showed in the diabetic nephropathy and elevated blood pressure perfused hindlimb preparation of subtotally nephrectomized rats that this is true not only for the renal, but also for the local renin-angiotensin system of the vessel wall.

In the kidney an important but not the sole mechanism, responsible for increased and unregulated renin secretion is luminal narrowing of preglomerular vessels because of vascular sclerosis.

Consequently the baroreceptor will measure a falsely low perfusion pressure analogous to the kidney with a Goldblatt clip on the renal artery. More renin will therefore be secreted. In subjects with healthy kidneys plasma renin activity falls asymptotically with increasing blood pressure. In contrast in patients with kidney disease renin secretion is inadequately suppressed and plasma renin activity remains inappropriately high.

In the past it was thought that the above two mechanisms i. Today we know that this concept is an oversimplification. DiBona et al 27 showed that the kidney contains chemoreceptors and baroreceptors. These receptors are stimulated in a diseased kidney Afferent signals then travel to the hypothalamus diabetic nephropathy and elevated blood pressure the activity of the centers controlling sympathetic tone is increased This causes elevation of the efferent diabetic nephropathy and elevated blood pressure nerve activity.

This phenomenon is not only important for the development of high blood pressure, but also for progression of kidney disease. Non-hypotensive doses of the central sympathicoplegic agent moxonidine reduced the development of glomerulosclosis and of albuminuria in subtotally nephrectomized rats That this effect is not unique to the centrally acting drug moxonidine diabetic nephropathy and elevated blood pressure shown by further experiments: metoprolol at doses which failed to affect systemic blood pressure 31or surgical denervation of the kidney had a similar renoprotective effects 28, This opens of course perspectives for the therapy of kidney diseases.

Is the sympathetic activity elevated in humans with kidney diseases as well? Converse et al 32 was the first to use microneurographic techniques and to document that sympathetic activity of the sural nerve was increased in dialysis tiens termékek diabétesz kezelésére. The number of discharges was doubled in hemodialyzed patients with chronic renal failure as compared to controls.

On the other hand if the non-functional kidneys of dialysed patients had been removed by binephrectomy the frequency of discharges was completely normalized Recently, Hausberg et al 34 showed that correction of uremia by kidney transplantation did not normalise elevated sympathetic nervous activity.

It was normalized, however, by nephrectomy of the recipients own kidneys. These observations provide evidence that afferent signals emanating from the kidney cause sympathetic overactivity in humans as well. Interestingly there are interactions diabetic nephropathy and elevated blood pressure the renin angiotensin system and sympathetic nerve system.

A plazma Apelin-szint és a diabéteszes nephropathia közötti kapcsolat 2-es típusú cukorbetegeknél

Ligtenberg et al 35 found that the elevated sympathetic activity of patients with chronic renal failure decreased after administration of an angiotensin converting enzyme inhibitor.

The same was recently showed by Klein et al 36 with respect to angiotensin II receptor type 1 blocker. This could be one of the reasons why angiotensin converting enzyme inhibitors and angiotensin II receptor type 1 blockers prevent progression zherlygin diabétesz kezelésére kidney diseases.

In this context there is of interest, that endothelial dysfunction has been demonstrated, which is in part due to reduced nitric oxide NO production This leads to reduced endothelial cell dependent vasodilation An elevated plasma concentration of ADMA was found even in renal patients with normal inulin clearance According to our observations in vitro, a complementary abnormality reducing NO dependent vasodilation, is reduced NO bioavailability in uremic rats 41 and patients 42 presumably secondary to scavanging by reactive oxigen species.

In any case, endothelial NO dependent diabetic nephropathy and elevated diabetic nephropathy and elevated blood pressure pressure is impaired in uremia, contributing to increased total peripheral resistance.

In summary, a number of factors participate in the pathogenesis of hypertension of patients with kidney disease: disturbed pressure-natriuresis relationship causing sodium retention, inappropriately high activity of renin-angiotensin system increased activity of the sympathetic nervous system and endothelial cell dysfunction leading to reduced vasodilation. In the past, the misconception prevailed that blood pressure increased only once glomerular filtration rate was markedly reduced.

gomba ujja cukorbetegség kezelésében a diabetes mellitus kezelése által méh subormal otthon

Diabetic nephropathy and elevated blood pressure view is definitely not correct. In children with a nephrotic syndrome, Küster et al 43 found that blood pressure values were systematically higher during the nephrotic episode than after remission of the disease.

That a reduction of whole kidney glomerular filtration rate GFR is not a prerequisite for the increase in blood pressure was also shown by Stefanski et al Table 1 In patients with biopsy-confirmed IgA glomerulonephritis and normal inulin clearance, he observed higher 24 h blood pressure values and this was accompanied by greater septal thickness and evidence of impaired compliance of the left ventricle.

Thus blood pressure especially nighttime blood pressure increases and leads to target organ injury even when overall GFR is still normal.

A diabétesz mellitus II. Típusú jagudin gyógyszerészeti tulajdonságai

A normal overall GFR does of course not preclude loss of nephrons since single nephron GFR is compensatorily increased in the remnant nephrons. Consequently we propose that such patients should be treated with antihypertensive drugs even when blood pressure values are still in the range of normotension. Whilst undoubtedly renal disease causes hypertension, there is increasing evidence that a genetic predisposition to hypertension increases the risk to develop renal disease.

This has been shown in patients with glomerulonephritis Table 2 Blood pressure values were higher in the parents of Table 2. The same is true for diabetic nephropathy.

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Higher blood pressure values were found in parents of type 1 diabetic patients with as compared to parents of patients without nephropathy Strojek et al 47 found higher blood pressure values by ambulatory blood pressure measurement in offsprings of type diabetic nephropathy and elevated blood pressure diabetic patients with, as compared to offsprings of type 2 diabetic parents without diabetic nephropathy Table 3.

In the offsprings of diabetic parents with nephropathy, blood pressure was also sodium-dependent compared to offsprings of diabetic parents without hypertension.

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The increased salt sensitivity is therefore possibly an interesting intermediate phenotype predisposing to the development of kidney disease. Table 3.

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There has been increasing recognition in recent years that elevation of blood pressure or frank hypertension are factors of overriding importance in the progression of renal failure. The deleterious effect of high blood pressure values on progression has first been proven by observational studies in diabetic 48, 49 and later non-diabetic renal disease However, observational studies do not prove causality. To this end, interventional studies are necessary. Meanwhile, it has been shown that lowering of blood pressure by antihypertensive medication attenuates progression of renal insufficiency both in patients with diabetic and nondiabetic renal disease Table 4.

Once the detrimental effect of high blood pressure on progression of renal disease had been established, Table 4. There is a continuous increase of renal risk with increasing blood pressure without a definite threshold. One piece of observation comes from the study of Opelz et al 51 that in renal graft recipients as one model of renal damage 6 year graft survival is progressively worse for increasing levels of systolic blood pressure measured 1 year after kidney transplantation at diabetic nephropathy and elevated blood pressure time when postoperative technical and immunological problems have mostly been eliminated.

The relationship between systolic blood pressure and graft function was especially impressive in young graft recipients.

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In young recipients even more so than in adults systolic blood pressure values still in the normal range significantly increased the risk of transplant failure. Interestingly systolic blood pressure was much more predictive than mean or diastolic blood pressure.

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This observation is surprising because normally the glomerulus is protected against the pulsatile variation of blood pressure in the aorta by the high resistance of preglomerular arteries. This paradoxical observation can be rationalized with the concept that in the acutely injured kidney afferent preglomerular vessels vasodilate as a response to the acute injury.

Such dilated vessels are not able to autoregulate to the pressure load, so that aortic blood pressure, and its pulsatile variation, can be more easily transmitted into the glomerular vascular bed, causing glomerular hypertension 52, In the long run, the afferent vessels will develop sclerotic lesions as well, further contributing to conduction of systemic pressure into the glomeruli.

The transplanted kidney graft is a good model of kidney injury and mutatis mutandis the same should be true for diabetic or nondiabetic kidney disease. One could diabetic nephropathy and elevated blood pressure that in hypertensive graft recipients an elevated systolic blood pressure only indicates that latent kidney injury is present which could not yet be detected by measuring serum creatinine concentrations.

For several reasons this is extremely unlikely. The most convincing argument comes from the observation that the same relationship between systolic blood pressure 1 year after transplantation and 7 year graft survival is found diabetic nephropathy and elevated blood pressure transplant recipients without any rejection episodes within the first year after transplantation.

In other words, high blood pressure is associated with long term outcome even in the absence of rejection. This observation is consistent with the hypothesis that blood pressure is, at least in part, the cause, and not the consequence, of kidney malfunction.

The concept that there is a continuous increase of renal risk with increasing blood pressure without a definite threshold has recently been confirmed by a meta-analysis of all controlled intervention trials in patients with non-diabetic renal disease. The best renal prognosis was found in individuals with systolic blood pressure values lower than mmhg Peterson et al 55 analysed the data of The Modification of Diet in Renal Disease Study MDRD and showed that in patients with proteinuric renal disease a direct relationship existed between achieved blood pressure and loss of renal function.

The lower the achieved mean arterial pressure values, the lower the rate of loss of glomerular filtration rate GFR. A minimum rate of loss cukorbetegség soványság GFR was seen when a mean arterial blood pressure of mmhg was reached.

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