New dimensions in the treatment of muscle spasticity after stroke and nervous system defects First-in-class antispastic drug candidate to reach clinical phase is published in the prestigious life science journal, Cell.
Drug candidate MPH could mean new hope for millions of patients suffering from spasticity. Currently, there is no satisfying remedy to help these suffering people, which generates an immense medical need for a new generation antispastic drug.
Among others, it cleaves natriuretic peptides which have a significant role in the pathomechanism of heart failure. This work is a review of literature They have been used to treat depression, however new evidence has shown
András Málnási-Csizmadia, co-founder of Motorpharma Ltd. MPH directly targets and inhibits the effector protein of muscle contraction, potentially by taking one pill per day. By contrast, current treatments have low efficacy and cause a wide range of side effects because they act indirectly, through the nervous system.
András Málnási-Csizmadia. The mechanism of action of MPH and preclinical studies are recently published in Cell. This feature of MPH makes it highly specific and safe.
James Spudich, co-founder new drug treatment drug treatment Cytokinetics, MyoKardia and Kainomyx, all companies developing drugs targeting cytoskeletal components, is also very excited about MPH as a possible next generation muscle relaxant. Skeletal myosin effectors, however, have not been reported. Motorpharma Ltd. A mimicked post-stroke spastic condition was generated by a specific brain surgery control and the same rat was treated by MPH MPH treated.
This business activity shows the demand for start-up biotech companies such as Myokardia or Motorpharma. A vázizmokban és a szívizomban működő miozinok nagyon hasonlóak egymáshoz, ezért meg kellett találni köztük azt az apró különbséget, amelynek kihasználásával a gyógyszerjelölt csak az egyikre hat.
András Málnási Csizmadia and Dr. Máté Gyimesi with the newly produced MPH antispastic drug candidate. You can change your cookie settings at any time in your browser settings.
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