Endocrinology impact factor, - kapcsolódó dokumentumok

Journal of Human Endocrinology

Pituitary adenoma xenografts were generated in immunocompromised mice. ASA decreased proliferation but did not induce apoptosis in pituitary cells. Inhibition of survivin using an inhibitor or siRNA-mediated silencing reversed the ASA-induced growth inhibition partially. We concluded that ASA inhibited the growth of pituitary adenoma cells.

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Survivin inhibition is a key mechanism explaining its antineoplastic effects. Beside cell cycle alterations, inhibition of apoptosis is also a potential mechanism leading to tumorigenesis in pituitary endocrinology impact factor.

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Proteomic studies also suggest deranged apoptosis in pituitary adenomas [ 7 ]. Survivin, a member of inhibitor of apoptosis protein IAP family, plays a role in both apoptosis inhibition and cell cycle regulation, although the mechanism of its action has not been clarified.

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Elevated survivin expression is present in a variety of cancers [ 8 ] and its expression correlates with aggressiveness and poor survival [ 910 ]. Thus, survivin is considered as a potential target in cancer therapies [ 11 ]. However, little is known about the role of survivin in pituitary tumors.

In a recent paper published while our work was in final preparations, the authors showed that survivin associated with invasiveness of pituitary adenomas [ 1012 ]. Endocrinology impact factor survivin is suppressed by acetylsalicylic acid ASAan agent used as chemoprevention for colorectal cancer [ 1314 ], we studied the endocrinology impact factor potential of ASA in pituitary tumours, and assess its potential effects on survivin.

Survivin as a potential therapeutic target of acetylsalicylic acid in pituitary adenomas

We hypothesized that ASA might affect various cellular processes through survivin, that could lead to reduced growth and beneficial overall effects. Now, we extended this study to GH-producing adenomas with 12 samples and we found that survivin mRNA was overexpressed compared to normal pituitary fold change: 4.

  1. NLM azonosító: Tudományos indexelő szolgáltatások azonosítója: A Journal of Human Endocrinology egy online szakértők által áttekintett, nemzetközi nyílt hozzáférésű folyóirat a ISSN:amely feltárja az endokrinológia újszerű tanulmányozását és innovatív kutatását.
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No cytoplasmic staining was observed. Analyzing moderate and strong positivity we found that

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