Supervisor: HEGYI, Eszter Chronic pancreatitis is a progressive inflammatory disease leading to irreversible morphological changes and impairment of both exocrine and endocrine functions. Genetics plays an important role in the pathogenesis of chronic pancreatitis, especially in children. Over the past 20 years the role of genetic factors in the etiology of chronic pancreatitis has been extensively studied and a mechanistic model in which premature trypsinogen activation plays a central pathogenic role has been established. More recently, an alternative pathomechanism unrelated to accelerated intrapancreatic trypsinogen activation has been revealed, in which mutation-induced misfolding and consequent ER stress lead to acinar cell damage and pancreatitis. Using animal models of genetically determined chronic pancreatitis we aim to study both pathomechanisms, the inzulinos cukorbetegség and the ER stress related pathways in vivo.
Many people with type 1 or type 2 diabetes use NNS as a replacement for nutritive sweeteners to control their carbohydrate and energy intake. Health outcomes associated with NNS use in diabetes are unknown.
- Kezelése típusú inzulin cukorbetegség 2
- An update on the conceptual and classification issues of anxiety, its neuroanatomy and problems of anxiolytic drug discovery.
The date of the last search of all databases except for Scopus was May We last searched Scopus in January We did not apply any language restrictions. Trials with concomitant behaviour-changing interventions, such as diet, exercise, or both, were eligible for inclusion, given that the concomitant interventions were the same in the intervention and comparator groups.
The intervention duration ranged from 4 to 10 months. We judged none of these trials as at low risk of bias for all 'Risk of bias' domains; most of the included trials did not report the method of randomisation.
Three trials compared the effects of a dietary supplement containing NNS with sugar: glycosylated haemoglobin A1c HbA1c was 0. The MD in weight change was None of the trials with sugar as comparator reported on adverse events.
Five trials compared NNS with placebo. One trial compared NNS with a nutritive low-calorie sweetener tagatose.
- Nyers zab a cukorbetegség kezelésére
- Diabetologia Hungarica
HbA1c was 0. This trial did not report body weight data and adverse events.
The included trials did not report data on health-related quality of life, diabetes complications, all-cause mortality, or socioeconomic effects. Data on health-related quality of life, diabetes complications, all-cause mortality, and socioeconomic effects are lacking.